Vinyl Chloride Bones

J toxicol environ health.

Vinyl chloride bones. Vinyl chloride disease is a syndrome consisting of raynaud s phenomenon acroosteolysis dissolution of the bones of the terminal phalanges and sacroiliac joints and scleroderma like skin changes. Vinyl chloride is a colorless gas that burns easily. Toxicity of vinyl chloride and polyvinyl chloride as seen through epidemiologic observations. Pvc is used to make a variety of plastic products including pipes wire and cable coatings and packaging materials.

High levels of vinyl chloride in the air also lead to blanching of fingers numbness discomfort changes in the bones at the end of the fingers joint and muscle pain and scleroderma like skin changes such as thickening of the skin decreased elasticity and slight edema. However it can be formed in the environment when other manufactured substances such as trichloroethylene trichloroethane and tetrachloroethylene are broken down by certain microorganisms. Wagoner jk infante pf apfeldorf rb. Repeated exposure can damage the skin scleroderma bones acro osteolysis and blood vessels in the hand raynaud s syndrome scleroderma is characterized by a hardening and tightening of patches of skin.

What is vinyl chloride. About 13 billion kilograms are produced annually. Vinyl chloride is primarily used to make polyvinyl chloride to manufacture plastics. Vinyl chloride monomer.

It does not occur naturally and must be produced industrially for its commercial uses. Vinyl chloride is a manufactured substance that does not occur naturally. Vinyl chloride is a chlorinated hydrocarbon occurring as a colorless highly flammable gas with a mild sweet odor that may emit toxic fumes of carbon dioxide carbon monoxide hydrogen chloride and phosgene when heated to decomposition. These exposures have resulted in what has been called vinyl chloride disease a syndrome consisting of raynaud s phenomenon blanching numbness and discomfort of the fingers upon exposure to cold degeneration of the fingertip bones acroosteolysis joint and muscle pain and stiffness of the hands with skin changes.

Vinyl chloride is used primarily to make polyvinyl chloride pvc. Oncogenic response of rat skin lungs and bones to vinyl chloride.